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Monoclinic form of Trypanosoma cruzi trans-sialidase
 
 
DOI:10.2210/pdb1ms3/pdb
1MS3
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Related Citations in PDB Entry (REMARK 1) Hide
     
     
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    Classification: Hydrolase
    Structure Weight: 142779.80
     
    Molecule:trans-sialidase
    Polymer:1Type:polypeptide(L)Length:648
    Chains:A, B
    EC#:3.2.1.18 Go to IUBMB EC entry  
    Fragment:enzymatic globular core
    Mutation:N58F,S495K,V496G,E520K,D593G,I597D,H599R
     
     
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    Polymer: 1
    Scientific Name: Trypanosoma cruzi Go to NCBI Taxonomy entry Expression System: Escherichia coli  
     
     
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    Id Details
    1MR5  Orthorhombic form of Trypanosoma cruzi trans-sialidase 
    1MS0  Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)and lactose 
    1MS1  Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA) 
    1MS4  Triclinic form of Trypanosoma cruzi trans-sialidase 
    1MS5  Triclinic form of Trypanosoma cruzi trans-sialidase, soaked with N-acetylneuraminyl-a-2,3-thio-galactoside (NA-S-Gal) 
    1MS8  Triclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA) 
    1MS9  Triclinic form of Trypanosoma cruzi trans-sialidase, in complex with lactose 
    1MZ5  Trypanosoma rangeli sialidase 
    1MZ6  Trypanosoma rangeli sialidase in complex with inhibitor DANA 
     
     
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< Biological Assembly 1    Help >
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Biological assembly 1 assigned by authors
 
 
 
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    Authors:   Buschiazzo, A.,   Amaya, M.F.,   Cremona, M.L.,   Frasch, A.C.,   Alzari, P.M.

    Deposition:   2002-09-19
    Release:   2003-03-25
    Last Modified (REVDAT):   2009-02-24
     
     
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    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   N/A
    View a histogram of Resolution Resolution[Å]: 1.65
    R-Value: 0.164 (obs.)
    R-Free: 0.192
    Space Group: P 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 63.22 α = 90.00 
    b = 128.85 β = 90.99 
    c = 86.62 γ = 90.00