Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion.
Cygler, M., Sivaraman, J., Grochulski, P., Coulombe, R., Storer, A.C., Mort, J.S.(1996) Structure 4: 405-416
- PubMed: 8740363 
- DOI: https://doi.org/10.1016/s0969-2126(96)00046-9
- Primary Citation of Related Structures:  
1MIR - PubMed Abstract: 
Cysteine proteases of the papain superfamily are synthesized as inactive precursors with a 60-110 residue N-terminal prosegment. The propeptides are potent inhibitors of their parent proteases. Although the proregion binding mode has been elucidated for all other protease classes, that of the cysteine proteases remained elusive.
Organizational Affiliation: 
Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada.