1MBK

MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3


Experimental Data Snapshot

  • Method: SOLUTION NMR
  • Conformers Submitted: 50 

wwPDB Validation   3D Report Full Report


This is version 1.3 of the entry. See complete history


Literature

Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb.

Ogata, K.Morikawa, S.Nakamura, H.Hojo, H.Yoshimura, S.Zhang, R.Aimoto, S.Ametani, Y.Hirata, Z.Sarai, A.Ishii, S.Nishimura, Y.

(1995) Nat Struct Biol 2: 309-320

  • DOI: https://doi.org/10.1038/nsb0495-309
  • Primary Citation of Related Structures:  
    1MBE, 1MBF, 1MBG, 1MBH, 1MBJ, 1MBK

  • PubMed Abstract: 

    The DNA-binding domain of c-Myb consists of three imperfect tandem repeats (R1, R2 and R3). The three repeats have similar overall architectures, each containing a helix-turn-helix variation motif. The three conserved tryptophans in each repeat participate in forming a hydrophobic core. Comparison of the three repeat structures indicated that cavities are found in the hydrophobic core of R2, which is thermally unstable. On complexation with DNA, the orientations of R2 and R3 are fixed by tight binding and their conformations are slightly changed. No significant changes occur in the chemical shifts of R1 consistent with its loose interaction with DNA.


  • Organizational Affiliation

    Graduate School of Integrated Science, Yokohama City University, Japan.


Macromolecules
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
MYB PROTO-ONCOGENE PROTEIN53Mus musculusMutation(s): 0 
UniProt & NIH Common Fund Data Resources
Find proteins for P06876 (Mus musculus)
Explore P06876 
Go to UniProtKB:  P06876
IMPC:  MGI:97249
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP06876
Sequence Annotations
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: SOLUTION NMR
  • Conformers Submitted: 50 

Structure Validation

View Full Validation Report



Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 1995-07-31
    Type: Initial release
  • Version 1.1: 2008-03-24
    Changes: Version format compliance
  • Version 1.2: 2011-07-13
    Changes: Version format compliance
  • Version 1.3: 2012-02-29
    Changes: Database references