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structure of the triple (Lys(beta)D3Ala, Asp(beta)C8Ala, AspCD2Ala) mutant of the Src SH2 domain bound to the PQpYEEIPI peptide
1KC2
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 12823.31
    Molecule: Src Tyrosine kinase
    Polymer: 1 Type: protein Length: 103
    Chains: A
    EC#: 2.7.10.2   
    Fragment: SH2 domain
    Mutation: D190A, D192A, K200A
    Organism: Rous sarcoma virus
    Gene Name: V-SRC
    UniProtKB: Protein Feature View | Search PDB | P00524  
    Molecule: PQpYEEIPI peptide
    Polymer: 2 Type: protein Length: 8
    Chains: B
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Rous sarcoma virus   Taxonomy   Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Synthetic construct   Taxonomy    
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    CO
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    CO Co
    COBALT (II) ION
     
  •   Modified Residues Hide
    Identifier Formula Parent Type
    PTR
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    PTR C9 H12 N O6 P TYR lPeptideLinking
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Lubman, O.Y.,  Waksman, G.

    Deposition:   2001-11-07
    Release:   2002-04-17
    Last Modified (REVDAT):   2009-02-24
     
  •   Revision History    Hide
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
    N/A
    Resolution[Å]:   2.10
    R-Value: 0.229 (obs.)
    R-Free: 0.267
    Space Group: I 4 2 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 62.45 α = 90.00 
    b = 62.45 β = 90.00 
    c = 133.68 γ = 90.00