A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).
Rano, T.A., Timkey, T., Peterson, E.P., Rotonda, J., Nicholson, D.W., Becker, J.W., Chapman, K.T., Thornberry, N.A.(1997) Chem Biol 4: 149-155
- PubMed: 9190289 
- DOI: https://doi.org/10.1016/s1074-5521(97)90258-1
- Primary Citation of Related Structures:  
1IBC - PubMed Abstract: 
Interleukin-1beta converting enzyme (ICE/caspase-1) is the protease responsible for interleukin-1beta (IL-1beta) production in monocytes. It was the first member of a new cysteine protease family to be identified. Members of this family have functions in both inflammation and apoptosis.
Organizational Affiliation: 
Department of Molecular Design and Diversity, Merck Research Laboratories, R123-232, PO Box 2000, Rahway, New Jersey 07065, USA.