1HZD

Crystal structure of human AUH protein, a single-stranded RNA binding homolog of enoyl-CoA hydratase.

(2001) Structure 9: 1253-1263

• PubMed: 11738050 Search on PubMed
• DOI: https://doi.org/10.1016/s0969-2126(01)00686-4


• PubMed Abstract: 
  

  The AU binding homolog of enoyl-CoA hydratase (AUH) is a bifunctional protein that has two distinct activities: AUH binds to RNA and weakly catalyzes the hydration of 2-trans-enoyl-coenzyme A (enoyl-CoA). AUH has no sequence similarity with other known RNA binding proteins, but it has considerable sequence similarity with enoyl-CoA hydratase. A segment of AUH, named the R peptide, binds to RNA. However, the mechanism of the RNA binding activity of AUH remains to be elucidated.

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Organizational Affiliation: 

Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-0033, Japan.