Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution.
Ding, J., Das, K., Tantillo, C., Zhang, W., Clark Jr., A.D., Jessen, S., Lu, X., Hsiou, Y., Jacobo-Molina, A., Andries, K., Pauwels, R., Moereels, H., Koymans, L., Janssen, P.A.J., Smith Jr., R.H., Koepke, M.K., Michejda, C.J., Hughes, S.H., Arnold, E.(1995) Structure 3: 365-379
- PubMed: 7542140 
- DOI: https://doi.org/10.1016/s0969-2126(01)00168-x
- Primary Citation of Related Structures:  
1HNI - PubMed Abstract: 
HIV-1 reverse transcriptase (RT) is a multifunctional enzyme that copies the RNA genome of HIV-1 into DNA. It is a heterodimer composed of a 66 kDa (p66) and a 51 kDa (p51) subunit. HIV-1 RT is a crucial target for structure-based drug design, and potent inhibitors have been identified, whose efficacy, however, is limited by drug resistance.
Organizational Affiliation: 
Center for Advanced Biotechnology and Medicine (CABM), Piscataway, NJ 08854-5638, USA.