1H3Z

Structural Variation in Pwwp Domains

(2003) J Mol Biol 330: 571-576

• PubMed: 12842472 Search on PubMed
• DOI: https://doi.org/10.1016/s0022-2836(03)00470-4
• Primary Citation of Related Structures:  
  1H3Z


• PubMed Abstract: 
  

  The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C-terminal helical region and in the PWWP motif.

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Organizational Affiliation: 

MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK.