The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin.
Xiang, S., Nichols, J., Rajagopalan, K.V., Schindelin, H.(2001) Structure 9: 299-310
- PubMed: 11525167 
- DOI: https://doi.org/10.1016/s0969-2126(01)00588-3
- Primary Citation of Related Structures:  
1G8L, 1G8R - PubMed Abstract: 
Molybdenum cofactor (Moco) biosynthesis is an evolutionarily conserved pathway present in archaea, eubacteria, and eukaryotes. In humans, genetic abnormalities in the biosynthetic pathway result in Moco deficiency, which is accompanied by severe neurological symptoms and death shortly after birth. The Escherichia coli MoeA and MogA proteins are involved in the final step of Moco biosynthesis: the incorporation of molybdenum into molybdopterin (MPT), the organic pyranopterin moiety of Moco.
Organizational Affiliation: 
Department of Physiology and Biophysics, State University of New York at Stony Brook, 11794, USA.