Download MendeleyAnnexin V--heparin oligosaccharide complex suggests heparan sulfate--mediated assembly on cell surfaces.
Capila, I., Hernaiz, M.J., Mo, Y.D., Mealy, T.R., Campos, B., Dedman, J.R., Linhardt, R.J., Seaton, B.A.(2001) Structure 9: 57-64
- PubMed: 11342135
- DOI: https://doi.org/10.1016/s0969-2126(00)00549-9
- Primary Citation of Related Structures:
1G5N - PubMed Abstract:
Annexin V, an abundant anticoagulant protein, has been proposed to exert its effects by self-assembling into highly ordered arrays on phospholipid membranes to form a protective anti-thrombotic shield at the cell surface. The protein exhibits very high-affinity calcium-dependent interactions with acidic phospholipid membranes, as well as specific binding to glycosaminoglycans (GAGs) such as heparin and heparan sulfate, a major component of cell surface proteoglycans. At present, there is no structural information to elucidate this interaction or the role it may play in annexin V function at the cell surface.
Organizational Affiliation:
Division of Medicinal and Natural Products Chemistry, Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA.
