The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex.
Randal, M., Kossiakoff, A.A.(2001) Structure 9: 155-163
- PubMed: 11250200 
- DOI: https://doi.org/10.1016/s0969-2126(01)00567-6
- Primary Citation of Related Structures:  
1FYH - PubMed Abstract: 
Interferon-gamma (IFN-gamma) is a homodimeric cytokine that exerts its various activities by inducing the aggregation of two different receptors. The alpha chain receptor (IFN-gammaRalpha) is a high affinity receptor that binds to IFN-gamma in a symmetric bivalent manner to form a stable, intermediate 1:2 complex. This intermediate forms a binding template for the subsequent binding of two copies of the second receptor, beta chain receptor (IFN-gammaRbeta), producing the active 1:2:2 signaling complex.
Organizational Affiliation: 
Graduate Group in Biophysics, University of California, 94000, San Francisco, CA, USA.