Cross-Talk and Ammonia Channeling between Active Centers in the Unexpected Domain Arrangement of Glutamate Synthase
Binda, C., Bossi, R.T., Wakatsuki, S., Arzt, S., Coda, A., Curti, B., Vanoni, M.A., Mattevi, A.(2000) Structure 8: 1299
- PubMed: 11188694 
- DOI: https://doi.org/10.1016/s0969-2126(00)00540-2
- Primary Citation of Related Structures:  
1EA0 - PubMed Abstract: 
The complex iron-sulfur flavoprotein glutamate synthase catalyses the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine, a reaction in the plant and bacterial pathway for ammonia assimilation. The enzyme functions through three distinct active centers carrying out L-glutamine hydrolysis, conversion of 2-oxoglutarate into L-glutamate, and electron uptake from an electron donor.
Organizational Affiliation: 
Dipartimento di Genetica e Microbiologia, Università degli Studi di Pavia, Italy.