1DNY

Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases.

(2000) Structure 8: 407-418

• PubMed: 10801488 Search on PubMed
• DOI: https://doi.org/10.1016/s0969-2126(00)00120-9
• Primary Citation of Related Structures:  
  1DNY


• PubMed Abstract: 
  

  Nonribosomal peptide synthetases (NRPSs) are large modular enzymes responsible for the synthesis of a variety of microbial bioactive peptides. They consist of modules that each recognise and incorporate one specific amino acid into the peptide product. A module comprises several domains, which carry out the individual reaction steps. After activation by the adenylation domain, the amino acid substrate is covalently tethered to a 4'-phosphopantetheinyl cofactor of a peptidyl carrier domain (PCP) that passes the substrate to the reaction centres of the consecutive domains.

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Organizational Affiliation: 

Biochemie/Fachbereich Chemie, Philipps-Universität, Marburg, 35032, Germany.