Download MendeleyCrystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site.
Liao, D.I., Wolff, E.C., Park, M.H., Davies, D.R.(1998) Structure 6: 23-32
- PubMed: 9493264
- DOI: https://doi.org/10.1016/s0969-2126(98)00004-5
- Primary Citation of Related Structures:
1DHS - PubMed Abstract:
Eukaryotic initiation factor 5A (elF-5A) contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DHS). The modified version of elF-5A, and DHS, are required for eukaryotic cell proliferation. Knowledge of the three-dimensional structure of this key enzyme should permit the design of specific inhibitors that may be useful as anti-proliferative agents.
Organizational Affiliation:
Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD 20892-0560, USA.
