Novel fold and assembly of the repetitive B region of the Staphylococcus aureus collagen-binding surface protein.
Deivanayagam, C.C., Rich, R.L., Carson, M., Owens, R.T., Danthuluri, S., Bice, T., Hook, M., Narayana, S.V.(2000) Structure 8: 67-78
- PubMed: 10673425 
- DOI: https://doi.org/10.1016/s0969-2126(00)00081-2
- Primary Citation of Related Structures:  
1D2O, 1D2P - PubMed Abstract: 
[corrected] The Staphylococcus aureus collagen-binding protein Cna mediates bacterial adherence to collagen. The primary sequence of Cna has a non-repetitive collagen-binding A region, followed by the repetitive B region. The B region has one to four 23 kDa repeat units (B(1)-B(4)), depending on the strain of origin. The affinity of the A region for collagen is independent of the B region. However, the B repeat units have been suggested to serve as a 'stalk' that projects the A region from the bacterial surface and thus facilitate bacterial adherence to collagen. To understand the biological role of these B-region repeats we determined their three-dimensional structure.
Organizational Affiliation: 
Center for Macromolecular Crystallography, School of Optometry, University of Alabama at Birmingham, Birmingham, AL 35294-0005, USA.