Download MendeleyX-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution.
Li, C., Kappock, T.J., Stubbe, J., Weaver, T.M., Ealick, S.E.(1999) Structure 7: 1155-1166
- PubMed: 10508786
- DOI: https://doi.org/10.1016/s0969-2126(99)80182-8
- Primary Citation of Related Structures:
1CLI - PubMed Abstract:
The purine biosynthetic pathway in procaryotes enlists eleven enzymes, six of which use ATP. Enzymes 5 and 6 of this pathway, formylglycinamide ribonucleotide (FGAR) amidotransferase (PurL) and aminoimidazole ribonucleotide (AIR) synthetase (PurM) utilize ATP to activate the oxygen of an amide within their substrate toward nucleophilic attack by a nitrogen. AIR synthetase uses the product of PurL, formylglycinamidine ribonucleotide (FGAM) and ATP to make AIR, ADP and P(i).
Organizational Affiliation:
Department of Chemistry and Chemical Biology Cornell University Ithaca, New York 14853, USA.
