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GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE
1CJ1
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Signaling Protein
    Structure Weight: 142157.69
    Molecule: PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2)
    Polymer: 1 Type: protein Length: 96
    Chains: A, B, C, D, E, F, G, H, I, J, K, L
    Fragment: SH2 DOMAIN
    Details: COMPLEXED WITH PHOSPHOTYROSYL DERIVATIVE
    Organism: Homo sapiens
    Gene Names: Gene View for GRB2 ASH
    UniProtKB: Protein Feature View | Search PDB | P62993  
     
  •   Structure Validation Hide

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  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    C78
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    C78 C31 H42 N5 O9 P
    [1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)- CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)- ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER
    C78:1CJ1
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    C78
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    C78
    IC50: 1.6 nM (100) - data from BindingDB  
    N/Ain BindingMoad
    N/Ain PDBbind
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly 1       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Rahuel, J.

    Deposition:   1999-04-21
    Release:   1999-12-22
    Last Modified (REVDAT):   2009-02-24
     
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    2011-07-13
    Version format compliance
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   3.00
    R-Value: 0.305 (work)
    R-Free: 0.317
    Space Group: P 21 21 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 73.80 α = 90.00 
    b = 93.30 β = 90.00 
    c = 232.80 γ = 90.00