1BPV

The three-dimensional structure of a type I module from titin: a prototype of intracellular fibronectin type III domains.

(1998) Structure 6: 1291-1302

• PubMed: 9782056 Search on PubMed
• DOI: https://doi.org/10.1016/s0969-2126(98)00129-4
• Primary Citation of Related Structures:  
  1BPV


• PubMed Abstract: 
  

  Titin is a huge protein ( approximately 3 MDa) that is present in the contractile unit (sarcomere) of striated muscle and has a key role in muscle assembly and elasticity. Titin is mainly composed of two types of module (type I and II). Type I modules are found exclusively in the region of titin localised in the A band, where they are arranged in a super-repeat pattern that correlates with the ultrastructure of the thick filament. No structure of a titin type I module has been reported so far.

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Organizational Affiliation: 

EMBL Meyerhofstrasse 1, 69117, Heidelberg, Germany Institut de Biologie Structurale J-P Ebel 41 Avenue des Martyrs, 38027 Grenoble, France.