1B4F

Oligomeric structure of the human EphB2 receptor SAM domain.

(1999) Science 283: 833-836

• PubMed: 9933164 Search on PubMed
• DOI: https://doi.org/10.1126/science.283.5403.833
• Primary Citation of Related Structures:  
  1B4F


• PubMed Abstract: 
  

  The sterile alpha motif (SAM) domain is a protein interaction module that is present in diverse signal-transducing proteins. SAM domains are known to form homo- and hetero-oligomers. The crystal structure of the SAM domain from an Eph receptor tyrosine kinase, EphB2, reveals two large interfaces. In one interface, adjacent monomers exchange amino-terminal peptides that insert into a hydrophobic groove on each neighbor. A second interface is composed of the carboxyl-terminal helix and a nearby loop. A possible oligomer, constructed from a combination of these binding modes, may provide a platform for the formation of larger protein complexes.

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Organizational Affiliation: 

UCLA-DOE Laboratory of Structural Biology and Molecular Medicine and Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.