1APF

Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A.

(1995) Structure 3: 791-803

• PubMed: 7582896 Search on PubMed
• DOI: https://doi.org/10.1016/s0969-2126(01)00214-3
• Primary Citation of Related Structures:  
  1APF


• PubMed Abstract: 
  

  The polypeptide anthopleurin-B (AP-B) is one of a number of related toxins produced by sea anemones. AP-B delays inactivation of the voltage-gated sodium channel of excitable tissue. In the mammalian heart, this effect is manifest as an increase in the force of contraction. As a result, there is interest in exploiting the anthopleurins as lead compounds in the design of novel cardiac stimulants. Essential to this endeavour is a high-resolution solution structure of the molecule describing the positions of functionally important side chains.

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Organizational Affiliation: 

NMR Laboratory, Biomolecular Research Institute, Parkville, Australia.