Download MendeleyCrystal structure of Aeromonas proteolytica aminopeptidase: a prototypical member of the co-catalytic zinc enzyme family.
Chevrier, B., Schalk, C., D'Orchymont, H., Rondeau, J.M., Moras, D., Tarnus, C.(1994) Structure 2: 283-291
- PubMed: 8087555
- DOI: https://doi.org/10.1016/s0969-2126(00)00030-7
- Primary Citation of Related Structures:
1AMP - PubMed Abstract:
Aminopeptidases specifically cleave the amino-terminal residue from polypeptide chains and are involved in the metabolism of biologically active peptides. The family includes zinc-dependent enzymes possessing either one or two zinc ions per active site. Structural studies providing a detailed view of the metal environment may reveal whether the one-zinc and two-zinc enzymes constitute structurally and mechanistically distinct subclasses, and what role the metal ions play in the catalytic process.
Organizational Affiliation:
Laboratoire de Biologie Structurale, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.
