Download MendeleyThe structure of tobacco ringspot virus: a link in the evolution of icosahedral capsids in the picornavirus superfamily.
Chandrasekar, V., Johnson, J.E.(1998) Structure 6: 157-171
- PubMed: 9519407
- DOI: https://doi.org/10.1016/s0969-2126(98)00018-5
- Primary Citation of Related Structures:
1A6C - PubMed Abstract:
Tobacco ringspot virus (TRSV) is a member of the nepovirus genus of icosahedral RNA plant viruses that cause disease in fruit crops. Nepoviruses, comoviruses and picornaviruses are classified in the picornavirus superfamily. Crystal structures of comoviruses and picornaviruses and the molecular mass of the TRSV subunit (sufficient to accommodate three beta-barrel domains) suggested that nepoviruses may represent a link in the evolution of the picornavirus capsids from a T = 3 icosahedral virus. This evolutionary process is thought to involve triplication of the capsid protein gene, to encode a three-domain polyprotein, followed by development of cleavage sites in the interdomain linking regions. Structural studies on TRSV were initiated to determine if the TRSV subunit corresponds to the proposed uncleaved three-domain polyprotein.
Organizational Affiliation:
Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
