Download MendeleyThe structure of SAICAR synthase: an enzyme in the de novo pathway of purine nucleotide biosynthesis.
Levdikov, V.M., Barynin, V.V., Grebenko, A.I., Melik-Adamyan, W.R., Lamzin, V.S., Wilson, K.S.(1998) Structure 6: 363-376
- PubMed: 9551557
- DOI: https://doi.org/10.1016/s0969-2126(98)00038-0
- Primary Citation of Related Structures:
1A48 - PubMed Abstract:
The biosynthesis of key metabolic components is of major interest to biologists. Studies of de novo purine synthesis are aimed at obtaining a deeper understanding of this central pathway and the development of effective chemotherapeutic agents. Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase catalyses the seventh step out of ten in the biosynthesis of purine nucleotides. To date, only one structure of an enzyme involved in purine biosynthesis has been reported: adenylosuccinate synthetase, which catalyses the first committed step in the synthesis of AMP from IMP.
Organizational Affiliation:
Institute of Crystallography, Russian Academy of Sciences, Leninsky, Moscow. Vladimir@sunchem.chem.uga.edu
