CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN
1W1H
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 72594.56
    Molecule: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1
    Polymer: 1 Type: protein Length: 151
    Chains: A, B, C, D
    EC#: 2.7.11.1   
    Fragment: PLECKSTRIN HOMOLOGY DOMAIN, RESIDUES 409-556
    Organism: Homo sapiens
    Gene Names: Gene View for PDPK1 Gene View for PDK1
    UniProtKB: Protein Feature View | Search PDB | O15530  
     
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  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
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    Identifier Details
    1H1W   HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN PDK1 CATALYTIC DOMAIN 
    1OKY   STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE 
    1OKZ   STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH UCN-01 
    1UU3   STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH LY333531 
    1UU7   STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-2 
    1UU8   STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-1 
    1UU9   STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-3 
    1UVR   STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-8 
    1W1D   CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO INOSITOL (1, 3,4,5)-TETRAKISPHOSPHATE 
    1W1G   CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO DIC4- PHOSPHATIDYLINOSITOL (3,4,5)-TRISPHOSPHATE 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    GOL
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    GOL C3 H8 O3
    GLYCEROL
    SO4
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    SO4 O4 S
    SULFATE ION
     
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Data in orange boxes are gathered from external resources (when available).
  Biological Assembly 1       
Biological assembly 1 assigned by authors and generated by PQS (software)
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  •   Deposition Summary Hide
    Authors:   Komander, D.,  Deak, M.,  Alessi, D.R.,  Van Aalten, D.M.F.

    Deposition:   2004-06-21
    Release:   2004-11-19
    Last Modified (REVDAT):   2009-02-24
     
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
    N/A
    Resolution[Å]:   1.45
    R-Value: 0.157 (obs.)
    R-Free: 0.206
    Space Group: P 1 21 1
    Unit Cell:
      Length [Å] Angles [°]
    a = 42.69 α = 90.00 
    b = 65.28 β = 97.49 
    c = 101.12 γ = 90.00