CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO DIC4-PHOSPHATIDYLINOSITOL (3,4,5)-TRISPHOSPHATE
1W1G
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 18532.75
    Molecule: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1
    Polymer: 1 Type: protein Length: 151
    Chains: A
    EC#: 2.7.11.1   
    Fragment: PLECKSTRIN HOMOLOGY DOMAIN, RESIDUES 409-556
    Organism: Homo sapiens
    Gene Names: Gene View for PDPK1 Gene View for PDK1
    UniProtKB: Protein Feature View | Search PDB | O15530  
     
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  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
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    Identifier Details
    1H1W   HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN PDK1 CATALYTIC DOMAIN 
    1OKY   STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE 
    1OKZ   STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH UCN-01 
    1UU3   STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH LY333531 
    1UU7   STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-2 
    1UU8   STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-1 
    1UU9   STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-3 
    1UVR   STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-8 
    1W1D   CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO INOSITOL (1, 3,4,5)-TETRAKISPHOSPHATE 
    1W1H   CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    4PT
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    4PT C17 H36 O22 P4
    (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY- 3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}- 2-(1-HYDROXYBUTOXY)PROPYL BUTYRATE
    4PT:1W1G
     
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    Identifier   Binding Affinity (Sequence Identity %)
    4PT
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    4PT
    N/Ain BindingDB
    Ki: 21 nM - data from BindingMOAD  
    N/Ain PDBbind
     
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  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PQS (software)
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  •   Deposition Summary Hide
    Authors:   Komander, D.,  Deak, M.,  Alessi, D.R.,  Van Aalten, D.M.F.

    Deposition:   2004-06-21
    Release:   2004-11-19
    Last Modified (REVDAT):   2009-02-24
     
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    Resolution[Å]:   1.45
    R-Value: 0.183 (obs.)
    R-Free: 0.236
    Space Group: P 1 21 1
    Unit Cell:
      Length [Å] Angles [°]
    a = 35.26 α = 90.00 
    b = 58.94 β = 102.33 
    c = 36.44 γ = 90.00