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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-2
1UU7
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 36690.14
    Molecule: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1
    Polymer: 1 Type: protein Length: 310
    Chains: A
    EC#: 2.7.11.1   
    Fragment: KINASE DOMAIN, RESIDUES 51-360
    Organism: Homo sapiens
    Gene Names: Gene View for PDPK1 Gene View for PDK1
    UniProtKB: Protein Feature View | Search PDB | O15530  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Spodoptera frugiperda  
     
  •   Related PDB Entries Hide
    Identifier Details
    1H1W  HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN PDK1 CATALYTIC DOMAIN 
    1OKY  STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE 
    1OKZ  STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH UCN-01 
    1UU3  STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH LY333531 
    1UU8  STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-1 
    1UU9  STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-3 
    1UVR  STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-8 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    BI2
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    BI2 C27 H26 N4 O2
    3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}- 1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
    BI2:1UU7
    GOL
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    GOL C3 H8 O3
    GLYCEROL
    SO4
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    SO4 O4 S
    SULFATE ION
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    BI2
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    BI2
    IC50: 14000 nM (100) - data from BindingDB  
    IC50: 14000 nM - data from BindingMOAD  
    N/Ain PDBbind
     
  •   Modified Residues Hide
    Identifier Formula Parent Type
    SEP
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    SEP C3 H8 N O6 P SER lPeptideLinking
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PQS (software)
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