POP-OUT | CLOSE
 
Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target
1TW7
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Hydrolase
    Structure Weight: 21525.38
    Molecule: protease
    Polymer: 1 Type: protein Length: 99
    Chains: A, B
    EC#: 3.4.23.16   
    Mutation: L10I, D25N, M36V, M46L, I54V, I62V, L63P, A71V, V82A, I84V, L90M
    Organism: Human immunodeficiency virus 1
    Gene Name: pol
    UniProtKB: Protein Feature View | Search PDB | Q5RTL1  
     
  •   Structure Validation Hide

    Download full validation report    

     

  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
     
  •   Related PDB Entries Hide
    Identifier Details
    1RPI  MDR 769 uncomplexed 
    1RQ9  MDR 769 complexed with DMP450 (mozenavir) 
    1RV7  MDR 769 complexed with lopinavir 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    NA
    Search 
    Download 
    NA Na
    SODIUM ION
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
Downloadable viewers: