CRYSTAL STRUCTURE OF AP2V SUBSTRATE VARIANT OF NC-P1 DECAMER PEPTIDE IN COMPLEX WITH V82A/D25N HIV-1 PROTEASE MUTANT
1TSQ
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  •   Molecular Description Hide
    Classification: Hydrolase/viral Protein
    Structure Weight: 23326.46
    Molecule: Pol polyprotein
    Polymer: 1 Type: protein Length: 99
    Chains: A, B
    EC#: 3.4.23.16   
    Fragment: protease
    Mutation: Q7K,D25N,L63P,V82A
    Organism: HIV-1 M:B_ARV2/SF2
    Gene Name: gag-pol
    UniProtKB: Protein Feature View | Search PDB | P03369  
    Molecule: AP2V NC-P1 SUBSTRATE PEPTIDE
    Polymer: 2 Type: protein Length: 10
    Chains: P
    Mutation: AP2V
    Organism: HIV-1 M:B_HXB2R
    Gene Name: gag
    UniProtKB: Protein Feature View | Search PDB | P04591  
     
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  •   Source Hide
    Polymer: 1
    Scientific Name: Synthetic construct (HIV-1 M:B_ARV2/SF2)   Taxonomy    
    Polymer: 2
    Scientific Name: Synthetic construct (HIV-1 M:B_HXB2R)   Taxonomy    
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    ACT
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    ACT C2 H3 O2
    ACETATE ION
     
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Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Prabu-Jeyabalan, M.,  Nalivaika, E.A.,  King, N.M.,  Schiffer, C.A.

    Deposition:   2004-06-21
    Release:   2005-03-29
    Last Modified (REVDAT):   2009-02-24
     
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
    N/A
    Resolution[Å]:   2.00
    R-Value: 0.195 (obs.)
    R-Free: 0.231
    Space Group: P 21 21 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 50.77 α = 90.00 
    b = 57.26 β = 90.00 
    c = 60.92 γ = 90.00