Download MendeleyImmunoglobulin-like modules from titin I-band: extensible components of muscle elasticity.
Improta, S., Politou, A.S., Pastore, A.(1996) Structure 4: 323-337
- PubMed: 8805538
- DOI: https://doi.org/10.1016/s0969-2126(96)00036-6
- Primary Citation of Related Structures:
1TIT, 1TIU - PubMed Abstract:
The giant muscle protein titin forms a filament which spans half of the sarcomere and performs, along its length, quite diverse functions. The region of titin located in the sarcomere I-band is believed to play a major role in extensibility and passive elasticity of muscle. In the I-band, the titin sequence consists mostly of repetitive motifs of tandem immunoglobulin-like (Ig) modules intercalated by a potentially non-globular region. The highly repetitive titin architecture suggests that the molecular basis of its mechanical properties be approached through the characterization of the isolated components of the I-band and their interfaces. In the present paper, we report on the structure determination in solution of a representative Ig module from the I-band (I27) as solved by NMR techniques.
Organizational Affiliation:
EMBL, Meyerhofstrasse 1, D-69012 Heidelberg, Germany.
