Download MendeleyStructural similarity between TAFs and the heterotetrameric core of the histone octamer.
Xie, X., Kokubo, T., Cohen, S.L., Mirza, U.A., Hoffmann, A., Chait, B.T., Roeder, R.G., Nakatani, Y., Burley, S.K.(1996) Nature 380: 316-322
- PubMed: 8598927
- DOI: https://doi.org/10.1038/380316a0
- Primary Citation of Related Structures:
1TAF - PubMed Abstract:
A complex of two TFIID TATA box-binding protein-associated factors (TA FIIs) is described at 2.0A resolution. The amino-terminal portions of dTAFII42 and dTAFII62 from Drosophila adopt the canonical histone fold, consisting of two short alpha-helices flanking a long central alpha-helix. Like histones H3 and H4, dTAFII42 and dTAFII62 form an intimate heterodimer by extensive hydrophobic contacts between the paired molecules. In solution and in the crystalline state, the dTAFII42/dTAFII62 complex exists as a heterotetramer, resembling the (H3/H4)2 heterotetrameric core of the histone octamer, suggesting that TFIID contains a histone octamer-like substructure.
Organizational Affiliation:
Laboratory of Molecular Biophysics, The Rockefeller University, New York, 10021, USA.
