POP-OUT | CLOSE
MyPDB Login - Username: Password:

About: MyPDB stores and automatically runs your favorite queries. Email alerts are sent when matching structures are found.

    MyPDB Login
MyPDB: Login | Register
RCSB PDB Protein Data Bank | Home A Member of the wwPDB

An Information Portal to Biological Macromolecular Structures

As of Tuesday Feb 02, 2010 at 4 PM PST there are 63093 Structures RSS Feed for the Latest Released Structures Help | Latest Released  |  PDB Statistics Help | PDB Statistics
RCSB PDB Protein Data Bank | Home

Print Options: BW Safe Color Safe Print




URL:
 
 
crystal structure of inhibitor amprenavir in complex with a multi-drug resistant variant of HIV-1 protease (L63P/V82T/I84V)
 
 
DOI:10.2210/pdb1t7j/pdb
1T7J
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Hydrolase
    Structure Weight: 22405.41
     
    Molecule:Pol Polyprotein
    Polymer:1Type:polypeptide(L)Length:99
    Chains:A, B
    EC#:3.4.23.16 Go to IUBMB EC entry  
    Fragment:Protease
    Mutation:Q7K/K14R/V82T/I84V
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Human immunodeficiency virus 1 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1F7A  How Does A Symmetric Dimer Recognize An Asymmetric Substrate? A Substrate Complex Of HIV-1 Protease. 
    1T3R  HIV PROTEASE WILD-TYPE IN COMPLEX WITH TMC114 INHIBITOR 
     
     
  •  
    Move Section Ligand Chemical Component Hide
    Identifier Name Formula Interaction View Links
    478     {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]- 1-BENZYL-2-HYDROXY-PROPYL}
    -CARBAMIC ACID TETRAHYDRO- FURAN-3-YL ESTER     		C25 H35 N3 O6 S 3DLigand Explorer Link out to Ligand Expos:478 Link out to SuperLigands:478 Link out to SuperHapten:478
    ACT     ACETATE ION C2 H3 O2 3DLigand Explorer Link out to Ligand Expos:ACT Link out to SuperLigands:ACT Link out to SuperHapten:ACT
     
     
  •  
    Move Section Derived Data Hide
     
     
Reset Layout
 
 
  •  
    Move Section Deposition Summary Hide
    Authors:   King, N.M.,   Prabu-Jeyabalan, M.,   Nalivaika, E.A.,   Wigerinck, P.B.T.P.,   De Bethune, M.-P.,   Schiffer, C.A.

    Deposition:   2004-05-10
    Release:   2005-05-10
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   N/A
    View a histogram of Resolution Resolution[Å]: 2.20
    R-Value: 0.203 (work)
    R-Free: 0.244
    Space Group: P 21 21 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 51.07 α = 90.00 
    b = 59.34 β = 90.00 
    c = 61.82 γ = 90.00