POP-OUT | CLOSE
MyPDB Login - Username: Password:

About: MyPDB stores and automatically runs your favorite queries. Email alerts are sent when matching structures are found.

    MyPDB Login
MyPDB: Login | Register
RCSB PDB Protein Data Bank | Home A Member of the wwPDB

An Information Portal to Biological Macromolecular Structures

As of Tuesday Feb 02, 2010 at 4 PM PST there are 63093 Structures RSS Feed for the Latest Released Structures Help | Latest Released  |  PDB Statistics Help | PDB Statistics
RCSB PDB Protein Data Bank | Home

Print Options: BW Safe Color Safe Print




URL:
 
 
HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate
 
 
DOI:10.2210/pdb1t05/pdb   NDB ID: PD0537
1T05
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Transferase/dna
    Structure Weight: 131188.62
     
    Molecule:oligonucleotide template
    Polymer:1Type:polydeoxyribonucleotideLength:27
    Chains:T
    Molecule:oligonucleotide primer
    Polymer:2Type:polydeoxyribonucleotideLength:21
    Chains:P
    Molecule:POL polyprotein
    Polymer:3Type:polypeptide(L)Length:558
    Chains:A
    EC#:2.7.7.49 Go to IUBMB EC entry  
    Fragment:HIV-1 reverse transcriptase p66 subunit
    Mutation:Q258C, C280S
    Molecule:POL polyprotein
    Polymer:4Type:polypeptide(L)Length:437
    Chains:B
    EC#:2.7.7.49 Go to IUBMB EC entry  
    Fragment:HIV-1 reverse transcriptase p51 subunit
    Mutation:C280S
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Synthetic construct Go to NCBI Taxonomy entry  
    Polymer: 2
    Scientific Name: Synthetic construct Go to NCBI Taxonomy entry  
    Polymer: 3
    Scientific Name: Human immunodeficiency virus 1 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
    Polymer: 4
    Scientific Name: Human immunodeficiency virus 1 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1RTD  Structure of a catalytic complex of HIV-1 reverse transcriptase: Implications for nucleoside analog resistance 
    1T03  HIV-1 reverse transcriptase crosslinked to tenofovir terminated template-primer (complex P) 
     
     
  •  
    Move Section Ligand Chemical Component Hide
    Identifier Name Formula Interaction View Links
    GOL     GLYCEROL C3 H8 O3 3DLigand Explorer Link out to Ligand Expos:GOL Link out to SuperLigands:GOL Link out to SuperHapten:GOL
    MG     MAGNESIUM ION Mg 3DLigand Explorer Link out to Ligand Expos:MG Link out to SuperLigands:MG Link out to SuperHapten:MG
    TNV     [2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY]METHYL- TRIPHOSPHATE C9 H16 N5 O10 P3 3DLigand Explorer Link out to Ligand Expos:TNV Link out to SuperLigands:TNV Link out to SuperHapten:TNV
     
     
  •  
    Move Section Modified Residues Hide
    Identifier Name Formula Interaction View Links
    MRG N2-(3-MERCAPTOPROPYL)-2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE (parent: DG)(type: dnaLinking) C13 H20 N5 O7 P S 3D Ligand Explorer Link out to Ligand Expos:MRG Link out to SuperLigands:MRG Link out to SuperHapten:MRG 2D
    DDG 2',3'-DIDEOXY-GUANOSINE-5'-MONOPHOSPHATE (parent: DG)(type: dnaLinking) C10 H14 N5 O6 P 3D Ligand Explorer Link out to Ligand Expos:DDG Link out to SuperLigands:DDG Link out to SuperHapten:DDG 2D
     
     
  •  
    Move Section Derived Data Hide
     
     
Reset Layout
 
 
  •  
    Move Section Deposition Summary Hide
    Authors:   Tuske, S.,   Sarafianos, S.G.,   Ding, J.,   Arnold, E.

    Deposition:   2004-04-07
    Release:   2004-05-11
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   Download Structure Factors
    View a histogram of Resolution Resolution[Å]: 3.00
    R-Value: 0.253 (work)
    R-Free: 0.292
    Space Group: P 31 1 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 171.57 α = 90.00 
    b = 171.57 β = 90.00 
    c = 156.27 γ = 120.00