HIV-1 reverse transcriptase crosslinked to tenofovir terminated template-primer (complex P)     DOI:10.2210/pdb1t03/pdb   NDB ID: PD0536

1T03 Display Files close FASTA Sequence PDB File PDB File (Header) mmCIF File mmCIF File (Header) PDBML/XML File PDBML/XML File (Header) Download Files close FASTA Sequence PDB File (Text) PDB File (gz) mmCIF File mmCIF File (gz) PDBML/XML File PDBML/XML File (gz) Structure Factor (Text) Structure Factor (gz) Biological Assembly (gz) (A) Print this Page Share this Page close Email Delicious Stumble Google More... Link this Page

Primary Citation       Molecular Description Hide Classification: Transferase/antibody/dna Structure Weight: 177532.46   Molecule: Synthetic oligonucleotide template Polymer: 1 Type: polydeoxyribonucleotide Length: 27 Chains: T Molecule: Synthetic oligonucleotide primer Polymer: 2 Type: polydeoxyribonucleotide Length: 21 Chains: P Molecule: POL polyprotein Polymer: 3 Type: polypeptide(L) Length: 558 Chains: A EC#: 2.7.7.49    Fragment: Reverse transcriptase, p66 subunit Mutation: Q258C, C280S Molecule: POL polyprotein Polymer: 4 Type: polypeptide(L) Length: 437 Chains: B EC#: 2.7.7.49    Fragment: Reverse transcriptase, p51 subunit Mutation: C280S Molecule: monoclonal antibody light chain Polymer: 5 Type: polypeptide(L) Length: 211 Chains: L Fragment: Fab light chain domain Molecule: monoclonal antibody heavy chain Polymer: 6 Type: polypeptide(L) Length: 225 Chains: H Fragment: Fab heavy chain domain       Source Hide Polymer: 1 Scientific Name: Synthetic construct   Polymer: 2 Scientific Name: Synthetic construct   Polymer: 3 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli   Polymer: 4 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli   Polymer: 5 Scientific Name: Mus musculus Common Name: House mouse   Polymer: 6 Scientific Name: Mus musculus Common Name: House mouse         Related PDB Entries Hide Id Details 1N5Y  HIV-1 Reverse Transcriptase Crosslinked To Post-Translocation Aztmp-Terminated DNA (Complex P)  1N6Q  HIV-1 Reverse Transcriptase Crosslinked To Pre-Translocation Aztmp-Terminated DNA (Complex N)  1T05  HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate  2HMI  HIV-1 Reverse Transcriptase Complexed With A Double-Stranded DNA and Fab28        Ligand Chemical Component Hide Identifier Name Formula Interaction View Links MG     MAGNESIUM ION Mg Ligand Explorer       Modified Residues Hide Identifier Name Formula Interaction View Links MRG N2-(3-MERCAPTOPROPYL)-2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE (parent: DG)(type: dnaLinking) C13 H20 N5 O7 P S Ligand Explorer TFO [2-(6-AMINO-9H-PURIN-9-YL)-1-METHYLETHOXY]METHYLPHOSPHONIC ACID (parent: DA)(type: dnaLinking) C9 H14 N5 O4 P Ligand Explorer       Derived Data Hide SCOP Classification v1.75 - (7 Domains) CATH Classification v3.2.0 - (13 Domains) PFAM Classification - (7 Domains) GO Terms - (68 Terms)     Reset Layout

Biological Assembly     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly assigned by authors         Deposition Summary Hide Authors:   Tuske, S.,   Sarafianos, S.G.,   Ding, J.,   Arnold, E. Deposition:   2004-04-07 Release:   2004-05-11 Last Modified (REVDAT):   2009-02-24       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:    [ EDS ] Resolution[Å]: 3.10 R-Value: 0.256 (work) R-Free: 0.295 Space Group: P 32 1 2 Unit Cell:   Length [Å] Angles [°] a = 166.78 α = 90.00  b = 166.78 β = 90.00  c = 221.13 γ = 120.00        Structure Links Hide Molecule of the Month Features: Reverse Transcriptase