CRYSTAL STRUCTURE OF K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R165335     DOI:10.2210/pdb1sv5/pdb

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Primary Citation       Molecular Description Hide Classification: Transferase Structure Weight: 115189.18   Molecule: Reverse Transcriptase Polymer: 1 Type: polypeptide(L) Length: 560 Chains: A EC#: 2.7.7.49    Fragment: P66 SUBUNIT Mutation: K103N,C280S Molecule: Reverse Transcriptase Polymer: 2 Type: polypeptide(L) Length: 430 Chains: B EC#: 2.7.7.49    Fragment: P51 SUBUNIT Mutation: K103N,C280S       Source Hide Polymer: 1 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli   Polymer: 2 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli         Related PDB Entries Hide Id Details 1DLO    1HNI    1HNV    1S6P    1S6Q    1S9E    1S9G    1SUQ    1TVR    2HMI          Ligand Chemical Component Hide Identifier Name Formula Interaction View Links 65B     4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN- 4-YL}OXY)-3,5 -DIMETHYLBENZONITRILE C20 H15 Br N6 O Ligand Explorer       Derived Data Hide SCOP Classification v1.75 - (3 Domains) CATH Classification v3.2.0 - (9 Domains) PFAM Classification - (7 Domains) GO Terms - (68 Terms)     Reset Layout

Biological Assembly     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly assigned by authors and generated by PISA (software)         Deposition Summary Hide Authors:   Das, K.,   Arnold, E. Deposition:   2004-03-27 Release:   2004-05-11 Last Modified (REVDAT):   2009-02-24       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:    [ EDS ] Resolution[Å]: 2.90 R-Value: 0.255 (obs.) R-Free: 0.326 Space Group: C 2 Unit Cell:   Length [Å] Angles [°] a = 222.51 α = 90.00  b = 67.74 β = 107.47  c = 103.29 γ = 90.00        Structure Links Hide Molecule of the Month Features: Reverse Transcriptase