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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R185545
 
 
DOI:10.2210/pdb1suq/pdb
1SUQ
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Transferase
    Structure Weight: 115258.60
     
    Molecule:REVERSE TRANSCRIPTASE
    Polymer:1Type:polypeptide(L)Length:560
    Chains:A
    EC#:2.7.7.49 Go to IUBMB EC entry  
    Fragment:P66 SUBUNIT
    Mutation:L31V, C280S
    Molecule:REVERSE TRANSCRIPTASE
    Polymer:2Type:polypeptide(L)Length:430
    Chains:B
    EC#:2.7.7.49 Go to IUBMB EC entry  
    Fragment:P51 SUBUNIT
    Mutation:C280S
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Human immunodeficiency virus 1 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Human immunodeficiency virus 1 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1HNI  THE STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN A COMPLEX WITH THE NON-NUCLEOSIDE INHIBITOR ALPHA-APA R 95845 
    1HNV  THE STRUCTURE OF HIV-1 RT/TIBO R 86183 COMPLEX 
    1S6P  THE CRYSTAL STRUCTURE OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R100943 
    1S6Q  THE CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R147681 
    1S9E  THE CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R129385 
    1S9G  THE CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R120394 
    1SV5  THE CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R165335 
    2HMI  HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH A DOUBLE -STRANDED DNA AND FAB28 
     
     
  •  
    Move Section Ligand Chemical Component Hide
    Identifier Name Formula Interaction View Links
    185     (6-[4-(AMINOMETHYL)-2,6-DIMETHYLPHENOXY]- 2-{[4-(AMINOMETHYL)PHENYL]AMINO}-5
    -BROMOPYRIMIDIN- 4-YL)METHANOL     		C21 H16 Br N5 O2 3DLigand Explorer Link out to Ligand Expos:185 Link out to SuperLigands:185 Link out to SuperHapten:185
    MG     MAGNESIUM ION Mg 3DLigand Explorer Link out to Ligand Expos:MG Link out to SuperLigands:MG Link out to SuperHapten:MG
     
     
  •  
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Biological assembly assigned by authors and generated by PISA (software)
 
 
 
  •  
    Move Section Deposition Summary Hide
    Authors:   Das, K.,   Arnold, E.

    Deposition:   2004-03-26
    Release:   2004-05-11
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   Download Structure Factors  [ EDS External Link to EDS ]
    View a histogram of Resolution Resolution[Å]: 3.00
    R-Value: 0.262 (obs.)
    R-Free: 0.325
    Space Group: C 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 226.11 α = 90.00 
    b = 69.47 β = 106.82 
    c = 104.26 γ = 90.00