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Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
1S78
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 235728.99
    Molecule: Receptor protein-tyrosine kinase erbB-2
    Polymer: 1 Type: protein Length: 624
    Chains: A, B
    EC#: 2.7.10.1   
    Fragment: extracellular domain (residues 23-646)
    Organism: Homo sapiens
    Gene Names: Gene View for ERBB2 HER2 MLN19 NEU NGL
    UniProtKB: Protein Feature View | Search PDB | P04626  
    Molecule: Pertuzumab Fab light chain
    Polymer: 2 Type: protein Length: 214
    Chains: C, E
    Organism: Mus musculus
    UniProtKB: Protein Feature View | Search PDB | Q7Z3Y4  
    Molecule: Pertuzumab Fab heavy chain
    Polymer: 3 Type: protein Length: 226
    Chains: D, F
    Organism: Mus musculus
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Cricetulus griseus  
    Polymer: 2
    Scientific Name: Mus musculus   Taxonomy   Common Name: House mouse Expression System: Escherichia coli  
    Polymer: 3
    Scientific Name: Mus musculus   Taxonomy   Common Name: House mouse Expression System: Escherichia coli  
    Polymer: 4
    Scientific Name: Synthetic construct   Taxonomy    
    Polymer: 6
    Scientific Name: Synthetic construct   Taxonomy    
     
  •   Related PDB Entries Hide
    Identifier Details
    1L7I  Pertuzumab (2C4) Fab, uncomplexed 
    1N8Y  ErbB2 from rat, uncomplexed 
    1N8Z  ErbB2 from human, complexed with Herceptin (trastuzumab) Fab 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    BMA
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    BMA C6 H12 O6
    BETA-D-MANNOSE
    NAG
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    NAG C8 H15 N O6
    N-ACETYL-D-GLUCOSAMINE
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly 1       
Biological assembly 1 assigned by authors and generated by PISA (software)
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