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CRYSTAL STRUCTURE OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R100943
 
 
DOI:10.2210/pdb1s6p/pdb
1S6P
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Transferase
    Structure Weight: 115171.57
     
    Molecule:POL polyprotein [Contains: Reverse transcriptase]
    Polymer:1Type:polypeptide(L)Length:560
    Chains:A
    EC#:2.7.7.49 Go to IUBMB EC entry  
    Fragment:P66 SUBUNIT
    Mutation:YES
    Molecule:POL polyprotein [Contains: Reverse transcriptase]
    Polymer:2Type:polypeptide(L)Length:430
    Chains:B
    EC#:2.7.7.49 Go to IUBMB EC entry  
    Fragment:P51 SUBUNIT
    Mutation:YES
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Human immunodeficiency virus 1 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Human immunodeficiency virus 1 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1DLO   
    1HNI  1HNI IS THE STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN A COMPLEX WITH THE NON-NUCLEOSIDE INHIBITOR ALPHA-APA R 95845 
    1HNV  1HNV IS THE STRUCTURE OF HIV-1 RT/TIBO R 86183 COMPLEX 
    1S9G  1S9G IS THE STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH JANSSEN-R120394 
    1SV5  1SV5 IS THE STRUCTURE OF K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH JANSSEN-R165335 
    2HMI  2HMI IS HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH A DOUBLE -STRANDED DNA AND FAB28 
    IS6Q  IS6Q IS THE STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH JANSSEN-R147681 
    IS9E  1S9E IS THE STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH JANSSEN-R129385 
    ISUQ  ISUQ IS THE STRUCTURE OF K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH JANSSEN-R165335 
     
     
  •  
    Move Section Ligand Chemical Component Hide
    Identifier Name Formula Interaction View Links
    IET     1-(4-CYANO-PHENYL)-3-[2-(2,6-DICHLORO-PHENYL)- 1-IMINO-ETHYL]-THIOUREA C16 H12 Cl2 N4 S 3DLigand Explorer Link out to Ligand Expos:IET Link out to SuperLigands:IET Link out to SuperHapten:IET
    MG     MAGNESIUM ION Mg 3DLigand Explorer Link out to Ligand Expos:MG Link out to SuperLigands:MG Link out to SuperHapten:MG
     
     
  •  
    Move Section Derived Data Hide
     
     
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Biological assembly assigned by authors and generated by PISA (software)
 
 
 
  •  
    Move Section Deposition Summary Hide
    Authors:   Das, K.,   Arnold, E.

    Deposition:   2004-01-26
    Release:   2004-05-11
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   Download Structure Factors  [ EDS External Link to EDS ]
    View a histogram of Resolution Resolution[Å]: 2.90
    R-Value: 0.245 (obs.)
    R-Free: 0.312
    Space Group: C 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 226.70 α = 90.00 
    b = 67.40 β = 107.00 
    c = 104.30 γ = 90.00