Crystal structure of the human RORalpha ligand binding domain in complex with cholesterol sulfate at 2.2A
1S0X
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  •   Molecular Description Hide
    Classification: Hormone/growth Factor Receptor
    Structure Weight: 31981.22
    Molecule: Nuclear receptor ROR-alpha
    Polymer: 1 Type: protein Length: 270
    Chains: A
    Fragment: ligand binding domain
    Organism: Homo sapiens
    Gene Names: Gene View for RORA NR1F1 RZRA
    UniProtKB: Protein Feature View | Search PDB | P35398  
     
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  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Spodoptera frugiperda  
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    C3S
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    C3S C27 H46 O4 S
    CHOLEST-5-EN-3-YL HYDROGEN SULFATE
    C3S:1S0X
     
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Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors
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  •   Deposition Summary Hide
    Authors:   Kallen, J.,  Schlaeppi, J.M.,  Bitsch, F.,  Delhon, I.,  Fournier, B.

    Deposition:   2004-01-05
    Release:   2004-02-10
    Last Modified (REVDAT):   2009-02-24
     
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   2.20
    R-Value: 0.197 (obs.)
    R-Free: 0.209
    Space Group: P 1 21 1
    Unit Cell:
      Length [Å] Angles [°]
    a = 54.40 α = 90.00 
    b = 49.90 β = 97.80 
    c = 60.70 γ = 90.00