STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE
DOI:10.2210/pdb1rtd/pdb   NDB ID: PD0023
1RTD
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase/dna
    Structure Weight: 261136.37
    Molecule: DNA TEMPLATE FOR REVERSE TRANSCRIPTASE
    Polymer: 1 Type: dna Length: 27
    Chains: E, G
    Mutation: C2-THIOL TETHER AT TEMPLATE GUANINE 11
    Molecule: DNA PRIMER FOR REVERSE TRANSCRIPTASE
    Polymer: 2 Type: dna Length: 21
    Chains: F, H
    Fragment: PRIMER
    Mutation: C2-THIOL TETHER AT TEMPLATE GUANINE 11
    Molecule: PROTEIN (REVERSE TRANSCRIPTASE)
    Polymer: 3 Type: protein Length: 554
    Chains: A, C
    EC#: 2.7.7.49    2.7.7.7    3.1.26.13   
    Fragment: P61
    Mutation: P1K, Q258C, E478Q
    Organism: Human immunodeficiency virus 1
    Gene Name: gag-pol
    UniProtKB: Protein Feature View | Search PDB | P03366  
    Molecule: PROTEIN (REVERSE TRANSCRIPTASE)
    Polymer: 4 Type: protein Length: 440
    Chains: B, D
    EC#: 2.7.7.49    2.7.7.7    3.1.26.13   
    Fragment: P50
    Organism: Human immunodeficiency virus 1
    Gene Name: gag-pol
    UniProtKB: Protein Feature View | Search PDB | P04585  
     
  •   Structure Validation Hide

    View the full validation report  

     

  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Synthetic construct   Taxonomy    
    Polymer: 2
    Scientific Name: Synthetic construct   Taxonomy    
    Polymer: 3
    Scientific Name: Human immunodeficiency virus 1   Taxonomy   Expression System: Escherichia coli  
    Polymer: 4
    Scientific Name: Human immunodeficiency virus 1   Taxonomy   Expression System: Escherichia coli  
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    MG
    Search 
    Download 
    MG Mg
    MAGNESIUM ION
    TTP
    Search 
    Download 
    TTP C10 H17 N2 O14 P3
    THYMIDINE-5'-TRIPHOSPHATE
    TTP:1RTD
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    TTP
    Search 
    Download 
    TTP
    Ki: 61 nM (98) - data from BindingDB  
    N/Ain BindingMoad
    N/Ain PDBbind
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
  • Nucleic Acid Database Hide
    View the NDB ID associated with this structure:PD0023
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly 1       
Biological assembly 1 assigned by authors
Downloadable viewers:
 
 
 
  •   MyPDB Personal Annotations Hide
     
  •   Deposition Summary Hide
    Authors:   Chopra, R.,  Huang, H.,  Verdine, G.L.,  Harrison, S.C.

    Deposition:   1998-08-26
    Release:   1998-12-09
    Last Modified (REVDAT):   2009-02-24
     
  •   Revision History    Hide
    Mouse over text for details
    2011-07-13
    Version format compliance
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
    N/A
    Resolution[Å]:   3.20
    R-Value: 0.224 (obs.)
    R-Free: 0.298
    Space Group: P 21 21 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 78.84 α = 90.00 
    b = 150.70 β = 90.00 
    c = 280.88 γ = 90.00