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STRUCTURE OF A CATALYTIC COMPLEX OF HIV-1 REVERSE TRANSCRIPTASE: IMPLICATIONS FOR NUCLEOSIDE ANALOG DRUG RESISTANCE
 
 
DOI:10.2210/pdb1rtd/pdb   NDB ID: PD0023
1RTD
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Transferase/dna
    Structure Weight: 261136.37
     
    Molecule:DNA TEMPLATE FOR REVERSE TRANSCRIPTASE
    Polymer:1Type:polydeoxyribonucleotideLength:27
    Chains:E, G
    Mutation:C2-THIOL TETHER AT TEMPLATE GUANINE 11
    Molecule:DNA PRIMER FOR REVERSE TRANSCRIPTASE
    Polymer:2Type:polydeoxyribonucleotideLength:21
    Chains:F, H
    Fragment:PRIMER
    Mutation:C2-THIOL TETHER AT TEMPLATE GUANINE 11
    Molecule:PROTEIN (REVERSE TRANSCRIPTASE)
    Polymer:3Type:polypeptide(L)Length:554
    Chains:A, C
    EC#:2.7.7.49 Go to IUBMB EC entry  
    Fragment:P61
    Mutation:P1K, Q258C, E478Q
    Molecule:PROTEIN (REVERSE TRANSCRIPTASE)
    Polymer:4Type:polypeptide(L)Length:440
    Chains:B, D
    EC#:2.7.7.49 Go to IUBMB EC entry  
    Fragment:P50
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Synthetic construct Go to NCBI Taxonomy entry  
    Polymer: 2
    Scientific Name: Synthetic construct Go to NCBI Taxonomy entry  
    Polymer: 3
    Scientific Name: Human immunodeficiency virus 1 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
    Polymer: 4
    Scientific Name: Human immunodeficiency virus 1 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
     
     
  •  
    Move Section Ligand Chemical Component Hide
    Identifier Name Formula Interaction View Links
    MG     MAGNESIUM ION Mg 3DLigand Explorer Link out to Ligand Expos:MG Link out to SuperLigands:MG Link out to SuperHapten:MG
    TTP     THYMIDINE-5'-TRIPHOSPHATE C10 H17 N2 O14 P3 3DLigand Explorer Link out to Ligand Expos:TTP Link out to SuperLigands:TTP Link out to SuperHapten:TTP
     
     
  •  
    Move Section Derived Data Hide
     
     
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< Biological Assembly 1    Help >
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Biological assembly 1 assigned by authors
 
 
 
  •  
    Move Section Deposition Summary Hide
    Authors:   Chopra, R.,   Huang, H.,   Verdine, G.L.,   Harrison, S.C.

    Deposition:   1998-08-26
    Release:   1998-12-09
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   N/A
    View a histogram of Resolution Resolution[Å]: 3.20
    R-Value: 0.224 (obs.)
    R-Free: 0.298
    Space Group: P 21 21 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 78.84 α = 90.00 
    b = 150.70 β = 90.00 
    c = 280.88 γ = 90.00