1RAU

Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures.

(1992) Biochemistry 31: 8406-8414

• PubMed: 1382577 Search on PubMed
• DOI: https://doi.org/10.1021/bi00151a003
• Primary Citation of Related Structures:  
  1RAU


• PubMed Abstract: 
  

  A model for the solution structure of an RNA tetraplex, (rUGGGGU)4, has been obtained by two-dimensional NMR spectroscopy and molecular dynamics. The molecule is parallel stranded and Hoogsteen base-paired in 50 mM KCl, and it is so stable that three of its six imino protons have exchange half-lives measured in days at 40 degrees C. The tetraplex is stabilized by base stacking and by the hydrogen bonds in four G quartets and at least one U quartet. This is the first indication of the existence of U-quartet structures of which we are aware.

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Organizational Affiliation: 

Department of Chemistry, Yale University, New Haven, Connecticut 06511.