1QNZ

NMR structure of the 0.5b anti-HIV antibody complex with the gp120 V3 peptide

Experimental Data Snapshot

  • Method: SOLUTION NMR
  • Conformers Submitted: 1 

wwPDB Validation   3D Report Full Report


This is version 1.2 of the entry. See complete history. 


Literature

NMR Structure of an Anti-Gp120 Antibody Complex with a V3 Peptide Reveals a Surface Important for Co-Receptor Binding

Tugarinov, V., Zvi, A., Levy, R., Hayek, Y., Matsushita, S., Anglister, J.

(2000) Structure 8: 385-395

  • DOI: https://doi.org/10.1016/s0969-2126(00)00119-2
  • Primary Citation of Related Structures:  
    1QNZ

  • PubMed Abstract: 

    The protein 0.5beta is a potent strain-specific human immunodeficiency virus type 1 (HIV-1) neutralizing antibody raised against the entire envelope glycoprotein (gp120) of the HIV-1(IIIB) strain. The epitope recognized by 0.5beta is located within the third hypervariable region (V3) of gp120. Recently, several HIV-1 V3 residues involved in co-receptor utilization and selection were identified.

    • Organizational Affiliation: 

    Department of Structural Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel.


Macromolecules
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Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
0.5B ANTIBODY (HEAVY CHAIN)A [auth H]119Mus musculusMutation(s): 0 
UniProt
Find proteins for P01750 (Mus musculus)
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Go to UniProtKB:  P01750
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UniProt GroupP01750
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  • Reference Sequence
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Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
0.5B ANTIBODY (LIGHT CHAIN)B [auth L]112Mus musculusMutation(s): 0 
UniProt
Find proteins for P01665 (Mus musculus)
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Go to UniProtKB:  P01665
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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
GP120C [auth P]18Human immunodeficiency virus 1Mutation(s): 0 
UniProt
Find proteins for Q79416 (Human immunodeficiency virus 1)
Explore Q79416 
Go to UniProtKB:  Q79416
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UniProt GroupQ79416
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: SOLUTION NMR
  • Conformers Submitted: 1 

Structure Validation

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Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2000-06-03
    Type: Initial release
  • Version 1.1: 2013-08-07
    Changes: Database references, Derived calculations, Other, Source and taxonomy, Structure summary, Version format compliance
  • Version 1.2: 2018-01-17
    Changes: Database references