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CRYSTAL STRUCTURE OF 3TC-RESISTANT M184I MUTANT OF HIV-1 REVERSE TRANSCRIPTASE
 
 
DOI:10.2210/pdb1qe1/pdb
1QE1
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Transferase
    Structure Weight: 114151.20
     
    Molecule:REVERSE TRANSCRIPTASE, SUBUNIT P66
    Polymer:1Type:polypeptide(L)Length:558
    Chains:A
    EC#:2.7.7.49 Go to IUBMB EC entry  
    Fragment:SUBUNIT A (P66), RESIDUES 168-725
    Mutation:M184I,C280S
    Molecule:REVERSE TRANSCRIPTASE, SUBUNIT P51
    Polymer:2Type:polypeptide(L)Length:427
    Chains:B
    EC#:2.7.7.49 Go to IUBMB EC entry  
    Fragment:SUBUNIT B (P51), RESIDUES 168-594
    Mutation:M184I,C280S
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Human immunodeficiency virus type 1 bh10 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Human immunodeficiency virus type 1 bh10 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1C9R  contains the same protein in complex with a double stranded DNA fragment and a Fab monoclonal antibody fragment 
    1DLO  Structure of wild-type unliganded HIV-1 reverse transcriptase 
    2HMI  Structure of wild-type HIV-1 reverse transcriptase in complex with DNA and a Fab monoclonal antibody fragment 
     
     
  •  
    Move Section Derived Data Hide
     
     
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Biological assembly assigned by authors and generated by PISA (software)
 
 
 
  •  
    Move Section Deposition Summary Hide
    Authors:   Sarafianos, S.G.,   Das, K.,   Ding, J.,   Hughes, S.H.,   Arnold, E.

    Deposition:   1999-07-12
    Release:   1999-08-30
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   Download Structure Factors  [ EDS External Link to EDS ]
    View a histogram of Resolution Resolution[Å]: 2.85
    R-Value: 0.346 (obs.)
    R-Free: 0.346
    Space Group: C 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 238.60 α = 90.00 
    b = 72.70 β = 105.60 
    c = 95.30 γ = 90.00