Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase.
Monzani, P.S., Trapani, S., Thiemann, O.H., Oliva, G.(2007) BMC Struct Biol 7: 59-59
- PubMed: 17894860 
- DOI: https://doi.org/10.1186/1472-6807-7-59
- Primary Citation of Related Structures:  
1PZM - PubMed Abstract: 
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (EC 2.4.2.8) is a central enzyme in the purine recycling pathway. Parasitic protozoa of the order Kinetoplastida cannot synthesize purines de novo and use the salvage pathway to synthesize purine bases, making this an attractive target for antiparasitic drug design.
Organizational Affiliation: 
Departamento de Física e Informática, Grupo de Cristalografia de Proteínas e Biologia Estrutural, Instituto de Física de São Carlos, USP, Caixa Postal 369, 13560-590, São Carlos - SP, Brazil. monzani@if.sc.usp.br