HIV-1 Reverse Transcriptase Crosslinked to Post-Translocation AZTMP-Terminated DNA (Complex P)     DOI:10.2210/pdb1n5y/pdb   NDB ID: PD0365

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Primary Citation       Molecular Description Hide Classification: Transferase/immune System/dna Structure Weight: 176778.57   Molecule: 5'-D(*AP*TP*GP*C*TP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3' Polymer: 1 Type: polydeoxyribonucleotide Length: 27 Chains: T Other Details: DNA TEMPLATE Molecule: 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(ATM))-3' Polymer: 2 Type: polydeoxyribonucleotide Length: 21 Chains: P Other Details: DNA PRIMER Molecule: REVERSE TRANSCRIPTASE Polymer: 3 Type: polypeptide(L) Length: 558 Chains: A EC#: 2.7.7.49    Mutation: Q258C, C280S Other Details: p66 Molecule: REVERSE TRANSCRIPTASE Polymer: 4 Type: polypeptide(L) Length: 430 Chains: B EC#: 2.7.7.49    Mutation: C280S Other Details: p51 Molecule: monoclonal antibody (light chain) Polymer: 5 Type: polypeptide(L) Length: 211 Chains: L Fragment: FAB 28 Molecule: monoclonal antibody (heavy chain) Polymer: 6 Type: polypeptide(L) Length: 225 Chains: H Fragment: FAB 28       Source Hide Polymer: 1 Scientific Name: Synthetic construct   Polymer: 2 Scientific Name: Synthetic construct   Polymer: 3 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli   Polymer: 4 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli   Polymer: 5 Scientific Name: Mus musculus Common Name: House mouse   Polymer: 6 Scientific Name: Mus musculus Common Name: House mouse         Related PDB Entries Hide Id Details 1HYS  HIV-1 RT with RNA:DNA  1RTD  HIV-1 RT with DNA:DNA and dNTP  2HMI  HIV-1 RT with DNA:DNA        Ligand Chemical Component Hide Identifier Name Formula Interaction View Links MG     MAGNESIUM ION Mg Ligand Explorer       Modified Residues Hide Identifier Name Formula Interaction View Links MRG N2-(3-MERCAPTOPROPYL)-2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE (parent: DG)(type: dnaLinking) C13 H20 N5 O7 P S Ligand Explorer ATM 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE (parent: DT)(type: dnaLinking) C10 H14 N5 O7 P Ligand Explorer       Derived Data Hide SCOP Classification v1.75 - (7 Domains) CATH Classification v3.2.0 - (13 Domains) PFAM Classification - (7 Domains) GO Terms - (68 Terms)     Reset Layout

Biological Assembly     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly assigned by authors         Deposition Summary Hide Authors:   Sarafianos, S.G.,   Clark Jr., A.D.,   Das, K.,   Tuske, S.,   Birktoft, J.J.,   Ilankumaran, P.,   Ramesha, A.R.,   Sayer, J.M.,   Jerina, D.M.,   Boyer, P.L.,   Hughes, S.H.,   Arnold, E. Deposition:   2002-11-07 Release:   2003-01-28 Last Modified (REVDAT):   2009-02-24       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:   Resolution[Å]: 3.10 R-Value: 0.255 (obs.) R-Free: 0.285 Space Group: P 32 1 2 Unit Cell:   Length [Å] Angles [°] a = 166.70 α = 90.00  b = 166.70 β = 90.00  c = 221.12 γ = 120.00        Structure Links Hide Molecule of the Month Features: Reverse Transcriptase