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Viability of a drug-resistant HIV-1 protease mutant: structural insights for better antiviral therapy
 
 
DOI:10.2210/pdb1mt9/pdb
1MT9
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Hydrolase
    Structure Weight: 23288.77
     
    Molecule:PROTEASE RETROPEPSIN
    Polymer:1Type:polypeptide(L)Length:99
    Chains:A, B
    EC#:3.4.23.16 Go to IUBMB EC entry  
    Mutation:Q7K, D25N, L63P, V82A
    Molecule:p1-p6 Gag substrate decapeptide
    Polymer:2Type:polypeptide(L)Length:10
    Chains:P
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Human immunodeficiency virus 1 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Synthetic construct Go to NCBI Taxonomy entry  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1KJ4  Inactive wild-type HIV-1 protease (D25N) complexed with its Gag substrate peptide MA-CA. 
    1MT7   
    1MT8   
    1MTB   
    1MTR  HIV-1 PROTEASE COMPLEXED WITH A CYCLIC PHE-ILE-VAL PEPTIDOMIMETIC INHIBITOR 
     
     
  •  
    Move Section Ligand Chemical Component Hide
    Identifier Name Formula Interaction View Links
    PO4     PHOSPHATE ION O4 P 3DLigand Explorer Link out to Ligand Expos:PO4 Link out to SuperLigands:PO4 Link out to SuperHapten:PO4
     
     
  •  
    Move Section Derived Data Hide
     
     
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< Biological Assembly    Help
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Biological assembly assigned by authors and generated by PISA (software)
 
 
 
  •  
    Move Section Deposition Summary Hide
    Authors:   Prabu-Jeyabalan, M.,   Nalivaika, E.A.,   King, N.M.,   Schiffer, C.A.

    Deposition:   2002-09-20
    Release:   2003-01-07
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   N/A
    View a histogram of Resolution Resolution[Å]: 2.00
    R-Value: 0.179 (obs.)
    R-Free: 0.210
    Space Group: P 21 21 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 51.26 α = 90.00 
    b = 59.13 β = 90.00 
    c = 61.93 γ = 90.00