1MML

Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase.

(1995) Structure 3: 879-892

• PubMed: 8535782 Search on PubMed
• DOI: https://doi.org/10.1016/S0969-2126(01)00223-4
• Primary Citation of Related Structures:  
  1MML


• PubMed Abstract: 
  

  Reverse transcriptase (RT) converts the single-stranded RNA genome of a retrovirus into a double-stranded DNA copy for integration into the host genome. This process requires ribonuclease H as well as RNA- and DNA-directed DNA polymerase activities. Although the overall organization of HIV-1 RT is known from previously reported crystal structures, no structure of a complex including a metal ion, which is essential for its catalytic activity, has been reported.

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Organizational Affiliation: 

Waksman Institute, Rutgers University, Piscataway, NJ 08855, USA.