1LZS
STRUCTURAL CHANGES OF THE ACTIVE SITE CLEFT AND DIFFERENT SACCHARIDE BINDING MODES IN HUMAN LYSOZYME CO-CRYSTALLIZED WITH HEXA-N-ACETYL-CHITOHEXAOSE AT PH 4.0
- PDB DOI: https://doi.org/10.2210/pdb1LZS/pdb
- Classification: HYDROLASE (O-GLYCOSYL)
- Organism(s): Homo sapiens
- Mutation(s): No 
- Deposited: 1994-09-14 Released: 1995-04-20 
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.60 Å
- R-Value Observed: 0.170 
wwPDB Validation   3D Report Full Report
This is version 2.0 of the entry. See complete history. 
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
HUMAN LYSOZYME | 130 | Homo sapiens | Mutation(s): 0  EC: 3.2.1.17 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P61626 (Homo sapiens) Explore P61626  Go to UniProtKB:  P61626 | |||||
PHAROS:  P61626 GTEx:  ENSG00000090382  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P61626 | ||||
Sequence AnnotationsExpand | |||||
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Oligosaccharides
Entity ID: 2 | |||||
---|---|---|---|---|---|
Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | C, E | 4 | N/A | ||
Glycosylation Resources | |||||
GlyTouCan:  G01361SX GlyCosmos:  G01361SX GlyGen:  G01361SX |
Small Molecules
Ligands 1 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
NA Query on NA | F [auth A], G [auth B] | SODIUM ION Na FKNQFGJONOIPTF-UHFFFAOYSA-N |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.60 Å
- R-Value Observed: 0.170 
- Space Group: P 21 21 21
Unit Cell:
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 46.99 | α = 90 |
b = 162.25 | β = 90 |
c = 32.52 | γ = 90 |
Software Name | Purpose |
---|---|
PROLSQ | refinement |
Entry History 
Deposition Data
- Released Date: 1995-04-20  Deposition Author(s): Matsushima, M., Song, H.
Revision History (Full details and data files)
- Version 1.0: 1995-04-20
Type: Initial release - Version 1.1: 2008-03-24
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Non-polymer description, Version format compliance - Version 1.3: 2017-11-29
Changes: Derived calculations, Other - Version 2.0: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Atomic model, Data collection, Derived calculations, Structure summary