CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 1051U91
1LW2
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 116607.74
    Molecule: HIV-1 REVERSE TRANSCRIPTASE
    Polymer: 1 Type: protein Length: 560
    Chains: A
    EC#: 2.7.7.49    2.7.7.7    3.1.26.13   
    Fragment: p66
    Mutation: T215Y
    Organism: Human immunodeficiency virus 1
    Gene Name: gag-pol
    UniProtKB: Protein Feature View | Search PDB | P04585  
    Molecule: HIV-1 REVERSE TRANSCRIPTASE
    Polymer: 2 Type: protein Length: 440
    Chains: B
    EC#: 2.7.7.49    2.7.7.7    3.1.26.13   
    Fragment: p51
    Mutation: T215Y
    Organism: Human immunodeficiency virus 1
    Gene Name: gag-pol
    UniProtKB: Protein Feature View | Search PDB | P04585  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Human immunodeficiency virus 1   Taxonomy   Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Human immunodeficiency virus 1   Taxonomy   Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    1C0T   1C0T contains the same protein COMPLEXED WITH BM+21.1326 
    1C0U   1C0U contains the same protein COMPLEXED WITH BM+50.0934 
    1C1B   1C1B contains the same protein COMPLEXED WITH GCA-186 
    1C1C   1C1C contains the same protein COMPLEXED WITH TNK-6123 
    1DTQ   1DTQ contains the same protein COMPLEXED WITH PETT-1 
    1DTT   1DTT contains the same protein COMPLEXED WITH PETT-2 
    1EP4   1EP4 contains the same protein COMPLEXED WITH S-1153 
    1FK9   1FK9 contains the same protein COMPLEXED WITH DMP-226 (EFAVIRENZ) 
    1FKO   1FKO contains K103N MUTANT HIV-1 RT COMPLEXED WITH DMP-226 (EFAVIRENZ) 
    1FKP   1FKP contains K103N MUTANT HIV-1 RT COMPLEXED WITH NEVIRAPINE 
    1JKH   1JKH contains Y181C MUTANT HIV-1 RT COMPLEXED WITH DMP-226 (EFAVIRENZ) 
    1JLA   1JLA contains Y181C MUTANT HIV-1 RT COMPLEXED TNK-651 
    1JLB   1JLB contains Y181C MUTANT HIV-1 RT COMPLEXED WITH NEVIRAPINE 
    1JLC   1JLC contains Y181C MUTANT HIV-1 RT COMPLEXED WITH PETT-2 
    1JLE   1JLE contains Y188C MUTANT HIV-1 RT 
    1JLF   1JLF contains Y188C MUTANT HIV-1 RT COMPLEXED WITH NEVIRAPINE 
    1JLG   1JLG contains Y188C MUTANT HIV-1 RT COMPLEXED WITH UC-781 
    1JLQ   1JLQ contains the same protein COMPLEXED WITH 739W94 
    1KLM   1KLM contains the same protein COMPLEXED WITH BHAP (U-90152) 
    1LW0   1LW0 contains T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE 
    1LWC   1LWC contains M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE 
    1LWE   1LWE contains M41L/T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMN) IN COMPLEX WITH NEVIRAPINE 
    1LWF   1LWF contains MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMQ+M184V: M41L/D67N/K70R/M184V/T215Y) IN COMPLEX WITH NEVIRAPINE 
    1REV   1REV contains the same protein COMPLEXED WITH 9-CL-TIBO 
    1RT1   1RT1 contains the same protein COMPLEXED WITH MKC-442 
    1RT2   1RT2 contains the same protein COMPLEXED WITH TNK-651 
    1RT3   1RT3 contains AZT DRUG RESISTANT HIV-1 RT MUTANT (RTMC) COMPLEXED WITH 1051U91 
    1RT4   1RT4 contains the same protein COMPLEXED WITH UC-781 
    1RT5   1RT5 contains the same protein COMPLEXED WITH UC-10 
    1RT6   1RT6 contains the same protein COMPLEXED WITH UC-38 
    1RT7   1RT7 contains the same protein COMPLEXED WITH UC-84 
    1RTH   1RTH contains the same protein COMPLEXED WITH 1051U91 
    1RTI   1RTI contains the same protein COMPLEXED WITH HEPT 
    1RTJ   1RTJ contains the same protein 
    1VRT   1VRT contains the same protein COMPLEXED WITH NEVIRAPINE 
    1VRU   1VRU contains the same protein COMPLEXED WITH ALPHA-APA 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    PO4
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    PO4 O4 P
    PHOSPHATE ION
    U05
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    U05 C15 H14 N4 O3
    6,11-DIHYDRO-11-ETHYL-6-METHYL-9-NITRO-5H- PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE
    U05:1LW2
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    U05
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    U05
    IC50: 400 nM (98) - data from BindingDB  
    N/Ain BindingMoad
    N/Ain PDBbind
     
  •   Modified Residues Hide
    Identifier Formula Parent Type
    CSD
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    CSD C3 H7 N O4 S CYS lPeptideLinking
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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