SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
1KJ7
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Hydrolase
    Structure Weight: 23016.37
    Molecule: POL POLYPROTEIN
    Polymer: 1 Type: protein Length: 99
    Chains: A, B
    EC#: 3.4.23.16   
    Fragment: HIV-1 PROTEASE, RESIDUES 57-155
    Mutation: D25N,Q7K
    Organism: Human immunodeficiency virus 1
    Gene Name: gag-pol
    UniProtKB: Protein Feature View | Search PDB | P03369  
    Molecule: gag polyprotein
    Polymer: 2 Type: protein Length: 10
    Chains: P
    Fragment: P2-NUCLEOCAPSID SUBSTRATE PEPTIDE, RESIDUES 372-381
    Organism: Human immunodeficiency virus type 1 (JRCSF ISOLATE)
    Gene Name: gag-pol
    UniProtKB: Protein Feature View | Search PDB | P20875  
     
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  •   Source Hide
    Polymer: 1
    Scientific Name: Human immunodeficiency virus 1   Taxonomy   Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Synthetic construct (Human immunodeficiency virus type 1 (JRCSF ISOLATE))   Taxonomy    
     
  •   Related PDB Entries Hide
    Identifier Details
    1F7A   HOW DOES A SYMMETRIC DIMER RECOGNIZE AN ASYMMETRIC SUBSTRATE? A SUBSTRATE COMPLEX OF HIV-1 PROTEASE 
    1KJ4   SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES 
    1KJF   SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES 
    1KJG   SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES 
    1KJH   SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    ACT
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    ACT C2 H3 O2
    ACETATE ION
     
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  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Schiffer, C.A.

    Deposition:   2001-12-04
    Release:   2002-03-06
    Last Modified (REVDAT):   2009-02-24
     
  •   Revision History    Hide
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
    N/A
    Resolution[Å]:   2.00
    R-Value: 0.206 (obs.)
    R-Free: 0.249
    Space Group: P 21 21 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 51.51 α = 90.00 
    b = 59.43 β = 90.00 
    c = 61.74 γ = 90.00