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SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES
 
 
DOI:10.2210/pdb1kj4/pdb
1KJ4
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Hydrolase
    Structure Weight: 46234.70
     
    Molecule:POL polyprotein
    Polymer:1Type:polypeptide(L)Length:99
    Chains:A, B, C, D
    EC#:3.4.23.16 Go to IUBMB EC entry  
    Fragment:HIV-1 PROTEASE, RESIDUES 57-155
    Mutation:D25N,Q7K
    Molecule:gag polyprotein
    Polymer:2Type:polypeptide(L)Length:10
    Chains:P, S
    Fragment:MATRIX-CAPSID SUBSTRATE PEPTIDE, RESIDUES 127-136
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Human immunodeficiency virus 1 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Synthetic construct Go to NCBI Taxonomy entry  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1F7A  HOW DOES A SYMMETRIC DIMER RECOGNIZE AN ASYMMETRIC SUBSTRATE? A SUBSTRATE COMPLEX OF HIV-1 PROTEASE 
    1KJ7  SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES 
    1KJF  SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES 
    1KJG  SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES 
    1KJH  SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES 
     
     
  •  
    Move Section Ligand Chemical Component Hide
    Identifier Name Formula Interaction View Links
    ACT     ACETATE ION C2 H3 O2 3DLigand Explorer Link out to Ligand Expos:ACT Link out to SuperLigands:ACT Link out to SuperHapten:ACT
     
     
  •  
    Move Section Derived Data Hide
     
     
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< Biological Assembly 1    Help >
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Biological assembly 1 assigned by authors and generated by PISA (software)
 
 
 
  •  
    Move Section Deposition Summary Hide
    Authors:   Schiffer, C.A.

    Deposition:   2001-12-04
    Release:   2002-03-06
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   N/A
    View a histogram of Resolution Resolution[Å]: 2.90
    R-Value: 0.197 (obs.)
    R-Free: 0.248
    Space Group: I 2 2 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 91.65 α = 90.00 
    b = 93.81 β = 90.00 
    c = 118.17 γ = 90.00